IMMUNOBIOLOGY STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells
نویسندگان
چکیده
1Center for Surgery Research, Cleveland Clinic Foundation/Lerner Research Institute, OH; 2Case Comprehensive Cancer Center, Cleveland, OH; 3Department of Surgery, University of Pennsylvania Medical Center, Philadelphia; 4Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis; and 5Department of Transfusion Medicine and 6National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
منابع مشابه
STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
The clinical outcomes of dendritic cell (DC)-based immunotherapy remain disappointing, with DCs often displaying a tenuous capacity to complete maturation and DC1 polarization in the tumor host. Surprisingly, we observed that the capacity for successful DC1 polarization, including robust IL12p70 production, could be regulated by STAT-dependent events even prior to DC differentiation. Exposure o...
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